目的:探讨静脉内硝普钠联合透明质酸酶和尿激酶治疗透明质酸动脉栓塞大鼠腹壁皮肤缺血性病变的效果，比较添加硝普钠和不添加硝普钠......

Nanoparticles (NPs) have shown potential in cancer therapy,while a single administration conferring a satisfactory outco......

Currently,architecting a rational and efficient nanoplatform combing with multi-therapeutic modalities is highly obligat......

Hypertrophic scars are unfavorable skin diseases characterized by excessive collagen depo-sition.Although systemic treat......

Although approved as an alcohol-abuse drug,disulfiram(DSF)exhibited potential anticancer activity when chelated with cop......

Disulfide (DSF) has been proved good anti-tumor effect and even better with coadministration of Cu2+.In this work,we rep......

The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid (HA) and Ch......

This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGD-chlorambucil-quantum dots (HA-RGD-CL......

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A multifunctional drug delivery system (GNRs@mSiO2-HA-RGD) was developed by conjugating targeting ligand hyaluronic acid......

Reduction-sensitive polymers and conjugates have emerged as a fascinating class of biomedical materials that can be eleg......

In this study, a water-soluble chitosan derivative, N,O-carboxymethylchitosan (NOCC) has been synthesized.Hyaluronic aci......

Hyaluronic acid (HA) and polyethylene glycol (PEG) are widely recognized as biocompatible polymers[1],and "Click Chemis......

Polymer-drug conjugates,a novel nanoscale drug delivery system,have achieved fantastic developments over the decades[1].......

Ortho ester-based pH-responsive polymeric micelles have drawn much interest for delivery of antitumor drugs due to the p......

An amphiphilic hyaluronic acid derivate,redox-sensitive hyaluronic acid-deoxycholic acid(HA-ss-DOCA)conjugate,was succes......

Tumor metastasis accounts for 90 %of cancer-associated deaths and is almost inaccessible by chemotherapy,surgical operat......

BaCkground Nowadays,cancer is one of the most main causes leading to death,which seriously endangers human health and su......

Gold nanostructures (AuNSs) exhibit fascinating size-and shape-dependent electric, magnetic and optical properties and f......

Polymer based gene delivery systems have been widely studied for their safety and simple preparation compared with viral......

The hyaluronic acid (HA) fibers scaffold with a extracellular matrix mimic structure has been prepared via lyophilizatio......

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Low toxicity and high transfection efficiency are among the most important preconditions for selecting a non-viral gene ......

Breast cancer,the most common cancer affecting females,accounts for 16% of all kinds of women tumors[1].10,11-Methylened......

In recent years,nanosized CT contrast agents have attracted great interest as they have several advantages over small mo......

There has been an ever increasing interest in designing glutathione (GSH) sensitive drug delivery systems (DDS) to impro......

Nano/micro-based properties of hydrogels such as patterns and particles with drugs are important in tissue engineering.S......

In this work, a tumour targeted and multi-stimuli responsive drug delivery system has been developed for combining photo......

Synthetic nucleic acid vectors have exhibited a great potential in cancer therapy compared with viral vectors[1].To achi......

Sports-related injuries and disease features are related with the professional sportsmens effect of risk factors and the......

Purpose To assess the efficacy and safety of platelet-rich plasma(PRP)for treatment of knee osteoarthritis(OA)compared w......

Objective To use polyethyleneimine (PEI) coated Fe3O4 nanoparticles modified with hyaluronicacid (HA) to specifically ta......

Purpose Knee osteoarthritis(OA)is the most common articular disease characterized by articular cartilage lesion....

The aim of the present study was to investigate the protective effect of interleukin-1 receptor antagonist(IL-1Ra)releas......

Objective:Numerous meta-analyses have been conducted aiming to compare hyaluronic acid(HA)and placebo in treatingknee os......

The purpose of this article was to study the effect of hyaluronic acid (HA) on chondrocyte apoptosis in a rat osteoarthr......

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Functionalized gold nanocages(AuNCs)have drawn increasing attention in microRNA(miRNA)delivery application....

Advanced stimuli-responsive nanosystems have attracted significant attention in the field of tumor treatment1.In our pre......

Tissue engineering approaches combining biomaterials and neural stem cells(NSCs)represent a promising strategy in treatm......

Drug delivery with controllable release based on nanoscale carriers has received much attention in recent years....

Dry eye syndrome(DES)is a common disease causing by instable tear film induce ocular surface inflammation.In ophthalmolo......

It is hard to realize structural and functional regeneration of critical osteochondral defects spontaneously by inherent......

Herein, a redox sensitive hyaluronic acid-decorated graphene oxide (HA-ss-GO) has been successfully synthesized as a nov......

The design of targeted polymer-drug conjugate capable of controlled drug release remains a benchmark for drug delivery s......

Paclitaxel (PTX) is an antitumor drug which has been widely adopted in clinical treatment of cancer for years.However, i......

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Stimuli-responsive delivery systems have been increasingly ultilized to promote physiological specificity and on-demand ......

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